A Natural First Assumption

Tingling, numbness or pain in the hand — particularly in the thumb, index and middle fingers — is frequently assumed to be carpal tunnel syndrome by default, given how common and well-known that condition is.

The Double Crush Phenomenon

A peripheral nerve can be compressed or irritated at more than one point along its course, and an early, often subclinical compression at one site — commonly the cervical spine or thoracic outlet — can make the nerve significantly more vulnerable to becoming symptomatic at a second, more distal site such as the carpal tunnel, a phenomenon first formally described as the "double crush" syndrome (Upton & McComas, 1973).

Why This Changes the Assessment

This means tingling in the hand can genuinely originate from, or be significantly contributed to by, cervical radiculopathy, thoracic outlet syndrome, or more proximal nerve entrapments — sometimes with a completely normal carpal tunnel. A thorough assessment typically screens the entire course of the nerve from the cervical spine down, rather than assuming the wrist is automatically the source simply because that is where symptoms are felt most intensely.

References & Further Reading

  1. Upton AR, McComas AJ. The double crush in nerve-entrapment syndromes. Lancet. 1973;2(7825):359-362.